ACYCLOVIR (NOVIRAX) CREAM 15GM

ACYCLOVIR (NOVIRAX) 5% Cream – 15 g

Manufacturer: Drug International Ltd.
Indication: Treatment of recurrent herpes labialis (cold sores) caused by herpes simplex virus (HSV‑1/2) in immunocompetent adults and adolescents aged 12 years and older.

🧪 Mechanism of Action

Acyclovir is a synthetic purine nucleoside analogue that inhibits viral DNA replication. It is selectively activated by the HSV-encoded enzyme thymidine kinase, leading to the formation of acyclovir triphosphate, which interferes with viral DNA polymerase and terminates viral DNA chain elongation.

💊 Dosage and Administration

• Dosage: Apply a 1 cm ribbon of cream to the affected area five times daily for four days.
• Initiation: Begin treatment as early as possible following the onset of signs or symptoms of herpes labialis (during the prodrome or when lesions appear).
• Application: Clean and dry the affected area before application. Wash hands thoroughly before and after applying the cream.

⚠️ Contraindications

• Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.

🧬 Pharmacokinetics

• Absorption: Minimal systemic absorption following topical application.
• Metabolism: Converted to acyclovir monophosphate by viral thymidine kinase, then to diphosphate and triphosphate by cellular enzymes.
• Excretion: Primarily excreted unchanged in the urine.

🧾 Storage

Store at room temperature between 20°C to 25°C (68°F to 77°F). Keep the tube tightly closed and out of reach of children.

💡 Additional Information

• Pregnancy Category: B. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Lactation: It is not known whether acyclovir is excreted in human milk. Caution should be exercised when administering to nursing mothers.
• Pediatric Use: Safety and effectiveness in pediatric patients less than 12 years of age have not been established.
• Geriatric Use: Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

Note: This information is provided for educational purposes only and is not intended as medical advice. Always consult a healthcare professional before starting any new medication.