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Description
ACNOTREN 10 mg Capsules (30’s) contain Isotretinoin 10 mg, a potent oral retinoid for severe, treatment-resistant acne (e.g., nodular or cystic acne) .
🧪 Key Information
- Composition: Isotretinoin 10 mg per softgel capsule (pharm.cals.am)
- Mechanism of Action: Reduces sebum production, shrinks sebaceous glands, normalises keratinisation, and exerts anti-inflammatory effects (Dwaey)
✅ Indications
- Severe nodular or cystic acne unresponsive to standard therapy (antibiotics, topicals)
- Acne that may cause permanent scarring (WebMD, Dwaey)
⚙️ Dosage & Administration
- Typical starting dose: 0.5 mg/kg/day, often split into two doses
- Possible adjustment: Up to 1–2 mg/kg/day based on response and tolerance (Vinmec International Hospital, Dwaey)
- Duration: 16–24 weeks (4–6 months) with effects continuing for up to 8 weeks post-treatment (nhs.uk)
- Instructions: Take with food, swallow whole with a full glass of water (Vinmec International Hospital)
⚠️ Safety & Precautions
- Teratogenicity: Strict contraception required in women of childbearing potential; negative pregnancy tests before, during, and after therapy (mayoclinic.org)
- Common side effects: Dry skin, lips, eyes, nosebleeds (Drugs.com)
- Serious risks: Elevated liver enzymes, cholesterol, triglycerides; mood changes; headaches; gastrointestinal or visual disturbances
🔍 Monitoring Requirements
- Baseline and periodic tests: liver function, lipids
- Regular clinical follow-up for side effects, mental health, pregnancy status in women
ACNOTREN is one of the most effective treatments available for severe acne when used under close medical supervision.
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