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Description
ACUPAN 20mg/2mL Injection (5’s)
ACUPAN is an injectable analgesic containing 20 mg of nefopam hydrochloride per 2 mL ampoule. It is used for the short-term relief of moderate to severe acute pain, including postoperative, dental, musculoskeletal, and acute traumatic pain. Nefopam is a non-opioid, centrally acting analgesic with minimal sedative and respiratory depressant effects.(Vinmec International Hospital, Scab Pharmacy, DrugBank)
Key Features:
- Mechanism of Action: Nefopam inhibits the reuptake of neurotransmitters serotonin, norepinephrine, and dopamine, contributing to its analgesic effects. (Wikipedia)
- Administration: Can be administered via deep intramuscular (IM) injection or slow intravenous (IV) infusion over 15 minutes. (Base de Données Publique des Médicaments)
- Dosage: The usual recommended dose is 20 mg per injection. If necessary, it can be repeated every 4 hours, without exceeding 120 mg/day. (admin.greenbook.nafdac.gov.ng)
- Onset of Action: Provides rapid analgesia, typically within 15–30 minutes.
- Duration of Action: Analgesic effects generally last 4–6 hours.
Precautions:
- Contraindications: Not recommended for individuals with a history of convulsive disorders or those who have recently taken monoamine oxidase inhibitors (MAOIs). (Wikipedia)
- Caution: Use with caution in patients with urinary retention or those at risk of urinary retention. (Medsafe)
- Elderly: May be more susceptible to side effects; dosage adjustments may be necessary.
Side Effects:
- Common: Nausea, sweating, dizziness, dry mouth, and light-headedness. (Wikipedia)
- Less Common: Vomiting, blurred vision, drowsiness, insomnia, headache, confusion, hallucinations, tachycardia, and aggravation of angina. (Wikipedia)
Storage:
- Conditions: Store at room temperature, away from light.
- Shelf Life: Refer to the expiration date on the packaging.
Note: ACUPAN should be administered by healthcare professionals in a clinical setting. Patients should be monitored for any adverse reactions during and after administration. Always follow the prescribed dosage and administration guidelines.
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