Description
NEXIZOST Acyclovir 250 mg IV Injection
NEXIZOST is a brand of intravenous acyclovir injection manufactured by Novo Medi Sciences Pvt. Ltd. Each vial contains 250 mg of acyclovir in a sterile solution intended for slow intravenous infusion. This formulation is designed for the treatment of severe herpes virus infections, including herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. (novomedi.com, Drugs.com)
Indications:
- Severe initial genital herpes in immunocompromised patients
- Herpes simplex encephalitis
- Neonatal herpes simplex infections
- Herpes zoster (shingles) in immunocompromised individuals
- Herpes simplex infections in immunocompromised patients
- Prophylaxis of herpes simplex infections in immunocompromised patients
- Varicella zoster infections
- Herpes simplex infections in neonates and infants up to three months of age (Medicines.org.uk, Medinfo Galway, Rad AR, Medicines.org.uk)
Dosage and Administration:
The recommended dosage of acyclovir for intravenous infusion varies based on the type of infection, the patient’s age, weight, and renal function. Typically, acyclovir is administered as a slow intravenous infusion over 1 hour every 8 hours. For adults with herpes simplex or varicella zoster infections, the usual dose is 5 mg/kg body weight every 8 hours, provided renal function is not impaired. In cases of herpes encephalitis or in immunocompromised patients, the dose may be increased to 10 mg/kg body weight every 8 hours. (Medicines.org.uk, MedlinePlus, Medicines.org.uk)
Side Effects:
Common side effects of acyclovir intravenous infusion may include:(Medinfo Galway)
- Nausea and vomiting
- Headache
- Diarrhea
- Phlebitis at the injection site
- Elevated liver enzymes
Serious side effects are rare but may include:
- Kidney problems (e.g., decreased urine output, swelling)
- Neurological symptoms (e.g., confusion, seizures)
- Blood disorders (e.g., low white blood cell count)
Patients receiving intravenous acyclovir should be adequately hydrated to minimize the risk of renal toxicity.
Storage:
Store acyclovir intravenous infusion at room temperature, away from light and moisture. Do not freeze. Keep out of reach of children. Reconstituted solutions should be used promptly and discarded if not used within the recommended time frame.
Note: This information is provided for educational purposes only. Always consult a healthcare professional before starting any new medication.
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