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Medicine

ACYCLOVIR (SIMPLOVIR) 250 IV 1’S

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SKU:

GENA141

Description

SIMPLOVIR 250 mg IV Infusion

Manufacturer: Incepta Pharmaceuticals Ltd.(Incepta Pharmaceuticals)

Presentation: Each box contains 1 vial of lyophilized acyclovir sodium equivalent to 250 mg acyclovir BP, along with 50 mL of 0.9% sodium chloride solution, a disposable syringe, and an infusion set. (Incepta Pharmaceuticals)

🧪 Mechanism of Action

Acyclovir is a synthetic purine nucleoside analogue that inhibits viral DNA replication. It is selectively activated by the herpes simplex virus (HSV)-encoded enzyme thymidine kinase, which converts acyclovir into acyclovir monophosphate. This monophosphate is further converted into diphosphate and triphosphate by cellular enzymes. The triphosphate form inhibits viral DNA polymerase and terminates the growing DNA chain. (Wikipedia)

💉 Indications

SIMPLOVIR 250 mg IV Infusion is indicated for the treatment of:

• Herpes simplex virus (HSV) infections in immunocompromised patients
• Severe initial genital herpes in non-immunocompromised patients(Medicines.org.uk)
• Varicella-zoster virus (VZV) infections(Drugs.com)
• Herpes simplex encephalitis(Wikipedia)
• Neonatal herpes simplex infections (MedlinePlus)

💊 Dosage and Administration

• Reconstitution: Reconstitute each 250 mg vial by adding 10 mL of Water for Injection or 0.9% sodium chloride solution. This provides a solution containing 25 mg/mL of acyclovir. (Medex)
• Administration: Administer by slow intravenous infusion over a one-hour period.(Alpha Medicare)
• Dosage Schedule: The recommended duration of treatment is 5 to 7 days for most infections and at least 10 days for herpes simplex encephalitis. (Medex)

⚠️ Contraindications

SIMPLOVIR 250 mg IV Infusion is contraindicated in patients with known hypersensitivity to acyclovir or valacyclovir. (Alpha Medicare)

🧪 Pharmacokinetics

• Absorption: After intravenous administration, acyclovir achieves high plasma concentrations.
• Distribution: Widely distributed in body fluids and tissues, including the cerebrospinal fluid.
• Metabolism: Minimal metabolism; primarily excreted unchanged in the urine.
• Elimination Half-Life: Approximately 2.5 to 3 hours in patients with normal renal function.

💊 Side Effects

Common side effects may include:

• Nausea
• Vomiting
• Headache
• Phlebitis at the injection site

Serious adverse reactions can occur, especially in patients with renal impairment or those receiving high doses. These may include:

• Renal toxicity(Wikipedia)
• Neurological effects such as confusion, seizures, and hallucinations(Medex)
• Hematological abnormalities

🧾 Storage

• Storage Conditions: Store at room temperature (20–25°C) in a dry place, protected from light.
• Shelf Life: Use reconstituted solution immediately; discard any unused portion.(Prachin Bangla)

🏥 Additional Information

• Hydration: Ensure adequate hydration during treatment to minimize the risk of renal complications.
• Monitoring: Regular monitoring of renal function is recommended during therapy.
• Pregnancy Category: Category B. (MedEasy)

Note: This information is provided for educational purposes only. Always consult a healthcare professional before initiating treatment with SIMPLOVIR 250 mg IV Infusion.