Description
COEMPAGEN 5/1000mg is a fixed-dose combination tablet containing 5 mg Empagliflozin and 1000 mg Metformin Hydrochloride, formulated to manage type 2 diabetes mellitus in adults. This combination therapy is designed to improve glycemic control, reduce the risk of cardiovascular events, and support weight management when used alongside diet and exercise.
Mechanism of Action:
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Empagliflozin: An SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, leading to increased urinary glucose excretion and lower blood glucose levels.
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Metformin Hydrochloride: A biguanide that decreases hepatic glucose production, reduces intestinal glucose absorption, and enhances insulin sensitivity.
Indications:
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To improve glycemic control in adults with type 2 diabetes mellitus.
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To reduce the risk of cardiovascular events such as heart attack or stroke in patients with type 2 diabetes and existing heart disease.
Dosage and Administration:
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The usual dosage is one tablet twice daily, taken with meals to reduce gastrointestinal side effects associated with metformin.
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Dosage may be adjusted based on individual medical conditions and response to treatment.
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It is essential to follow the prescribing physician’s instructions regarding dosage and timing.
Warnings and Precautions:
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Lactic Acidosis: A rare but serious side effect associated with metformin. Symptoms include muscle pain, fatigue, abdominal discomfort, and difficulty breathing.
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Dehydration: Empagliflozin may increase the risk of dehydration, leading to dizziness or fainting. Maintain adequate fluid intake.
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Ketoacidosis: May occur even in patients with normal blood glucose levels. Seek medical attention if symptoms like nausea, vomiting, or confusion arise.
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Hypoglycemia: Risk increases when combined with other antidiabetic agents like insulin or sulfonylureas.
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Renal Monitoring: Regular assessment of kidney function is recommended.
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Not for Type 1 Diabetes or Diabetic Ketoacidosis (DKA): Contraindicated in these conditions.
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Pregnancy and Lactation: Use is not recommended.
Side Effects:
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Common: Urinary tract infections, increased urination, nausea, diarrhea, and gastrointestinal discomfort.
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Rare: Allergic reactions, lactic acidosis, and severe dehydration.
Storage:
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Store below 30°C, protected from light and moisture.
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Keep out of the reach of children.
Note: This medication should be used under medical supervision. Always consult a healthcare provider before starting any new medication.
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