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DACILLIN CAP 300MG 10’S

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SKU:

PHAD004

Description

Dacillin 300mg Capsules (10’s) contain clindamycin, a lincosamide antibiotic effective against a variety of bacterial infections. Below is a comprehensive overview of this medication:

🩺 Indications

Dacillin 300mg is used to treat infections caused by susceptible anaerobic bacteria or certain gram-positive bacteria, including:

• Upper and lower respiratory tract infections

• Skin and soft tissue infections

• Bone and joint infections

• Pelvic infections

• Intra-abdominal infections

• Septicemia and endocarditis

• Dental infections

• Alternative therapy for multi-drug resistant Plasmodium falciparum infections

💊 Dosage and Administration

• Adults:

  • Serious infections: 150–300 mg every 6 hours.

  • Severe infections: 300–450 mg every 6 hours.

  • Maximum daily dose: 1.8 g.

  • For bone and joint infections or diabetic foot infections: 300 mg 3–4 times daily.

• Children:

  • 10–25 mg/kg/day in divided doses every 8 hours.

  • For more severe infections: 30–40 mg/kg/day

Note: To minimize the risk of esophageal irritation, take capsules with a full glass of water and remain upright for at least 30 minutes

⚠️ Side Effects

Common side effects may include:

• Nausea, vomiting, abdominal pain

• Diarrhea

• Skin rashes, pruritus

• Erythema multiforme

• Exfoliative dermatitis

• Urticaria

• Eosinophilia

• Local irritation at the injection site

• Thrombophlebitis

Serious adverse effects:

• Clostridium difficile-associated diarrhea (CDAD)

• Pseudomembranous colitis

• Severe allergic reactions (e.g., anaphylaxis)

• Hepatic dysfunction

• Renal impairment

Note: If you experience severe diarrhea, especially with blood or mucus, discontinue use and consult a healthcare professional immediately.

🧪 Mechanism of Action

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide bond formation and bacterial growth.

⚠️ Contraindications and Precautions

• Contraindications:

  • Hypersensitivity to clindamycin or lincomycin.Bissoy

• Precautions:

  • Use with caution in patients with a history of gastrointestinal disease, particularly colitis.

  • Monitor liver and kidney function during prolonged therapy.

  • Not recommended during pregnancy unless clearly needed.

  • Clindamycin is excreted in breast milk; use with caution during lactation.