Description
Lumartem Dry Syrup 60ml is a combination antimalarial medication containing Artemether 20 mg/5 ml and Lumefantrine 120 mg/5 ml. This formulation is designed to treat uncomplicated malaria caused by Plasmodium falciparum, particularly in children and adults who cannot swallow tablets.
Pharmacology:
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Artemether: An artemisinin derivative that rapidly reduces parasite biomass by generating free radicals that damage the parasite’s cell membrane.
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Lumefantrine: A lipophilic compound that eliminates residual parasites by inhibiting heme polymerization within the parasite’s food vacuole.
Dosage:
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The recommended dosage is based on body weight and administered over a 3-day period. For example:
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5 kg child: 2.5 ml every 12 hours for 3 days.
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10 kg child: 5 ml every 12 hours for 3 days.
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20 kg child: 10 ml every 12 hours for 3 days.
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It’s crucial to administer the syrup with food to enhance absorption, especially of Lumefantrine .
Administration:
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Reconstitute the syrup as per the manufacturer’s instructions.
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Ensure accurate dosing using the provided measuring device.
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Complete the full 3-day course, even if symptoms improve earlier, to prevent recrudescence.
Precautions:
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Not recommended for the prevention of malaria.
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Contraindicated in patients with a history of hypersensitivity to artemisinin derivatives or lumefantrine.
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Use with caution in individuals with a prolonged QT interval or those on medications that prolong the QT interval.
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Monitor for potential drug interactions, especially with medications metabolized by CYP3A4 and CYP2D6 .
Storage:
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Store in a cool, dry place, away from direct sunlight.
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Keep out of reach of children.
Note: Always consult a healthcare professional before starting any new medication.
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